Changes of microsomal membrane compositions modulate microsomal enzyme activity
نویسندگان
چکیده
منابع مشابه
Calorimetric study of microsomal membrane.
Differential scanning calorimetric measurements of normal rat liver microsomes reveal a single thermal transition at about 50 degrees. This transition is assigned to irreversible prorein denaturation. There is no evidence for a reversible lipid phase transition at any temperature above 0 degrees, indicating that the microsomal membrane is in teh fluid state under these conditions. Rats fed a fa...
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At both 4 and 24 hr after the administration of ethionine, female rats displayed a significant reduction in the RNA:pro tein ratio of liver microsomes. In this respect, ethionine behaved like many other hepatocarcinogens which induce ribosomal separation from the rough endoplasmic reticulum. This separation is usually brought about by the membrane, rather than ribosomal lesions. Using the disul...
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Signal recognition particle (SRP), an 11S ribonucleoprotein (Walter and Blobel (1982) Nature 299, 691-698), is required for translocation of secretory proteins across microsomal membranes (Walter and Blobel (1980) Proc. Natl. Acad. Sci. USA 77, 7112-7116) and for asymmetric integration into microsomal membranes of a transmembrane protein (Anderson et al., (1982) J. Cell Biol. 93, 501-506). We d...
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Studies were performed to determine the effects of an immunopotentiating agent, lentinan, on the hepatic drug-metabolizing enzymes in mice. Lentinan was injected twice a day for two days, and the enzyme activities were determined 12 hr after the last injection of lentinan. A lentinan dose of over 0.25 mg/kg was required to cause a significant decrease (20-40%) in the hepatic microsomal aminopyr...
متن کاملThe microsomal glucose-6-phosphatase enzyme of pancreatic islets.
Microsomal fractions isolated from pancreatic islet cells were shown to contain high specific glucose-6-phosphatase activity. The islet-cell glucose-6-phosphatase enzyme has the same Mr (36,500), similar immunological properties and kinetic characteristics to the hepatic microsomal glucose-6-phosphatase enzyme.
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1979
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197901000-00052